Known targets — ChEMBL curated mechanism
SLC6A2SLC6A3SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of D-Aspartate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | GSR | P00390 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL10954254 | 1.00 | GRIK1 (0.46) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL10954257 | 1.00 | GRIK1 (0.46) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL14742380 | 0.90 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL14742381 | 0.90 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL27966204 | 0.90 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL6941414 | 0.90 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GSR | |
| D-Aspartate SCHEMBL145539 | 0.87 | — | — | |
| Aspartic Acid SCHEMBL1526976 | 0.87 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GSR | |
| Aspartic Acid SCHEMBL3231 | 0.87 | — | — | |
| Aspartic Acid SCHEMBL11065189 | 0.87 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055665-A1 | DELIVERY CARRIER INTO CELL | ITO, KABUSIKIKAISYA (JP) | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055665-A1 | DELIVERY CARRIER INTO CELL | CTSA, ATG4A, ATG7 | GRIK1 3633/4885GRIK2 3398/4885GRM1 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.