Sugi Predict

Sugi Predict / Compounds / SCHEMBL3029561

SCHEMBL3029561

SCHEMBL3029561

CCc1ccc2[nH]c3c(c2c1)CN(C)CC3

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.67
▸ ALOX15 P16050 2/20 0.63
▸ HSD17B10 Q99714 2/20 0.63
▸ POLB P06746 2/20 0.63
▸ KDM4E B2RXH2 1/20 0.63
▸ ALDH1A1 P00352 1/20 0.63
▸ MAPK1 P28482 1/20 0.63
▸ USP2 O75604 1/20 0.62
▸ CYP1A2 P05177 1/20 0.62
▸ CYP2D6 P10635 1/20 0.62
▸ CYP2C9 P11712 1/20 0.62
▸ CHRNA7 P36544 1/20 0.61
▸ GAA P10253 1/20 0.59
▸ SIRT2 Q8IXJ6 1/20 0.58
▸ HTR6 P50406 6/20 0.57
▸ ACHE P22303 4/20 0.51
▸ GRIN1 Q05586 3/20 0.51
▸ GRIN2A Q12879 3/20 0.51
▸ GRIN2D O15399 2/20 0.51
▸ GRIN3B O60391 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20890503 0.89 CHRNA7 (0.61) L3MBTL1ALOX15HSD17B10POLBKDM4E
SCHEMBL3723963 0.88 L3MBTL1 (0.65) L3MBTL1ALOX15HSD17B10POLBKDM4E
Dehydrostobadine SCHEMBL167500 0.81 L3MBTL1 (0.97) L3MBTL1ALOX15HSD17B10POLBKDM4E
Dehydrostobadine SCHEMBL29468212 0.81 L3MBTL1 (0.97) L3MBTL1ALOX15HSD17B10POLBKDM4E
SCHEMBL13356240 0.80 L3MBTL1 (0.70) L3MBTL1ALOX15HSD17B10POLBKDM4E
SCHEMBL3024458 0.80 L3MBTL1 (0.70) L3MBTL1ALOX15HSD17B10POLBKDM4E
SCHEMBL19252850 0.80 L3MBTL1 (0.70) L3MBTL1ALOX15HSD17B10POLBKDM4E
Dehydrostobadine SCHEMBL2837548 0.80 L3MBTL1 (1.00) L3MBTL1ALOX15HSD17B10POLBKDM4E
Dehydrostobadine SCHEMBL3715610 0.80 L3MBTL1 (1.00) L3MBTL1ALOX15HSD17B10POLBKDM4E
SCHEMBL2186097 0.80 L3MBTL1 (0.70) L3MBTL1ALOX15HSD17B10POLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
US-9458155-B2 Pyrido[4,3-b]indoles containing rigid moieties MEDIVATION TECHNOLOGIES, INC (US) 2016-10-04 — — US disclosed
US-9181240-B2 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. (US) 2015-11-10 — — US disclosed
US-9096591-B2 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. (US) 2015-08-04 — — US disclosed
US-20150182509-A1 TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. 2015-07-02 — — US disclosed
US-9034880-B2 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. (US) 2015-05-19 — — US disclosed
US-8999978-B2 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. (US) 2015-04-07 — — US disclosed
US-20150051218-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2015-02-19 — — US disclosed
US-20150051218-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2015-02-19 — — US disclosed
US-20130190304-A1 TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. (US) 2013-07-25 — — US disclosed
US-20130131054-A1 TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. (US) 2013-05-23 — — US disclosed
US-8338408-B2 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. (US) 2012-12-25 — — US disclosed
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2010-08-26 — — US disclosed
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2010-08-26 — — US disclosed
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. 2010-08-26 — — US disclosed
EP-2217598-A1 NEW TETRACYCLIC COMPOUNDS Medivation Technologies, Inc. (US) 2010-08-18 — — EP disclosed
WO-2010051501-A1 PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. (US) 2010-05-06 — — WO disclosed
US-20090239854-A1 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. 2009-09-24 — — US disclosed
WO-2009055828-A1 NEW TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. (US) 2009-04-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051218-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES HTR3B, HTR3D, HTR3A L3MBTL1 2178/4885ALOX15 788/4885HSD17B10 2484/4885
US-20150182509-A1 TETRACYCLIC COMPOUNDS HTR2C, HTR3D, HTR5A L3MBTL1 3804/4885ALOX15 1350/4885HSD17B10 4035/4885
US-20130131054-A1 TETRACYCLIC COMPOUNDS HTR2C, HTR3D, HTR5A L3MBTL1 3804/4885ALOX15 1350/4885HSD17B10 4035/4885
US-20100216814-A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES HTR3B, HTR3D, HTR3A L3MBTL1 2178/4885ALOX15 788/4885HSD17B10 2484/4885
US-20130190304-A1 TETRACYCLIC COMPOUNDS HTR2C, HTR3D, HTR5A L3MBTL1 3804/4885ALOX15 1350/4885HSD17B10 4035/4885
US-20090239854-A1 Tetracyclic compounds HTR2C, HTR3D, HTR5A L3MBTL1 3804/4885ALOX15 1350/4885HSD17B10 4035/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.