Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.41 |
| ▸ | ARNT | P27540 | 3/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | PPOX | P50336 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30296282 | 1.00 | MERTK (0.42) | MERTKEPAS1ARNTHSPB1PDE7A | |
| SCHEMBL26132877 | 0.91 | ARNT (0.39) | MERTKEPAS1ARNTHSPB1PDE7A | |
| SCHEMBL11007687 | 0.81 | PDE7A (0.60) | HSPB1PDE7AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL30296504 | 0.79 | HTR2A (0.35) | EPAS1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL30050147 | 0.77 | MAPT (0.49) | MERTKHSPB1PDE7AMAPTSMN1; SMN2 | |
| SCHEMBL30296710 | 0.74 | MPO (0.38) | EPAS1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL11017217 | 0.72 | PIN1 (0.44) | MERTKEPAS1ARNTPDE7AMAPT | |
| SCHEMBL30050734 | 0.70 | MERTK (0.37) | MERTKEPAS1HSPB1PDE7AMAPT | |
| SCHEMBL29197501 | 0.70 | GRM5 (0.38) | MERTKEPAS1HSPB1PDE7AMAPT | |
| SCHEMBL30879410 | 0.69 | ALDH1A1 (0.46) | HSPB1PDE7AMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |