Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 10/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30296737 | 0.82 | EPHB4 (0.36) | FYNKCNH2DYRK1AS1PR4HDAC1 | |
| SCHEMBL31207379 | 0.81 | STIM1 (0.35) | PIK3CDFYNSTIM1ORAI1 | |
| SCHEMBL26457473 | 0.80 | PRKAG1 (0.49) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB | |
| SCHEMBL30296601 | 0.80 | PRKAG1 (0.49) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB | |
| SCHEMBL30296539 | 0.80 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB | |
| SCHEMBL30296556 | 0.78 | PIK3CA (0.43) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB | |
| SCHEMBL26458701 | 0.78 | PIK3CA (0.43) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB | |
| SCHEMBL30296380 | 0.78 | CYP11B2 (0.44) | PIK3CDFYNSTIM1ORAI1 | |
| SCHEMBL26456924 | 0.78 | CYP11B2 (0.44) | PIK3CDFYNSTIM1ORAI1 | |
| SCHEMBL31207371 | 0.76 | PRKAG1 (0.36) | PIK3CAPIK3CBPIK3CDPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| CN-118451080-A | Tricyclic GPR65 modulators | 帕蒂奥斯治疗有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | GPR65, GPR3, NR1H2 | PIK3CA 3336/4885PIK3CB 3333/4885PIK3CD 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.