Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 8/20 | 0.53 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202083 | 1.00 | ALOX15 (0.59) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL3961035 | 0.86 | KDM4E (0.58) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL3707866 | 0.86 | RAB9A (0.61) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL9974594 | 0.84 | XDH (0.47) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL7920033 | 0.83 | RAB9A (0.58) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL31609642 | 0.83 | RAB9A (0.58) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL2109109 | 0.82 | RAB9A (0.60) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL16839962 | 0.81 | GABRA1 (0.39) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL831147 | 0.80 | KDM4E (0.54) | ALOX15RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL30104780 | 0.80 | KDM4E (0.54) | ALOX15RAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402143-A1 | SPIROCYCLIC COMPOUNDS | Astrazeneca AB (SE) | 2024-07-24 | — | — | EP | disclosed |
| CN-117916241-A | Spiro compounds | 阿斯利康(瑞典)有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023036974-A1 | SPIROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2023-03-16 | — | — | WO | disclosed |