SCHEMBL3030993

SCHEMBL3030993

O=[N+]([O-])c1ccc(I)c(I)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
MEN1 O00255 1/20 0.56
HTT P42858 1/20 0.56
KMT2A Q03164 1/20 0.56
TSHR P16473 4/20 0.52
ALDH1A1 P00352 5/20 0.50
TDP1 Q9NUW8 3/20 0.50
HSD17B10 Q99714 2/20 0.50
PTPRC P08575 1/20 0.48
S100A4 P26447 1/20 0.48
GPR35 Q9HC97 2/20 0.47
CYP3A4 P08684 2/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HIF1A Q16665 1/20 0.47
TXNRD1 Q16881 1/20 0.45
TXNRD3 Q86VQ6 1/20 0.45
TXNRD2 Q9NNW7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10638495 0.84 PTPRC (0.57) LMNAMEN1HTTKMT2ATSHR
SCHEMBL790761 0.82 TDP1 (0.61) LMNAMEN1HTTKMT2ATSHR
SCHEMBL3836830 0.82 TDP1 (0.61) LMNAMEN1HTTKMT2ATSHR
SCHEMBL2569715 0.82 GPR35 (0.59) LMNAMEN1HTTKMT2ATSHR
SCHEMBL30414747 0.82 TDP1 (0.61) LMNAMEN1HTTKMT2ATSHR
SCHEMBL23779897 0.80 ALDH1A1 (0.62) LMNAMEN1HTTKMT2ATSHR
SCHEMBL482237 0.80 TSHR (0.62) LMNAMEN1HTTKMT2ATSHR
SCHEMBL16959133 0.80 TSHR (0.46) LMNAMEN1HTTKMT2ATSHR
SCHEMBL15201566 0.80 ALDH1A1 (0.47) LMNAMEN1HTTKMT2ATSHR
SCHEMBL527700 0.80 ALDH1A1 (0.67) LMNAMEN1HTTKMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10280304-B2 Polyarylene sulfide resin composition TEIJIN LIMITED (JP) 2019-05-07 US disclosed
US-10233327-B2 Polyarylene sulfide resin composition TEIJIN LIMITED (JP) 2019-03-19 US disclosed
EP-3103841-B1 POLYARYLENE SULFIDE RESIN COMPOSITION TEIJIN LTD (JP) 2018-09-26 EP disclosed
US-20180215918-A1 POLYARYLENE SULFIDE RESIN COMPOSITION TEIJIN LIMITED (JP) 2018-08-02 US disclosed
US-20160376439-A1 POLYARYLENE SULFIDE RESIN COMPOSITION TEIJIN LIMITED (JP) 2016-12-29 US disclosed
EP-3103841-A1 POLYARYLENE SULFIDE RESIN COMPOSITION Teijin Limited (JP) 2016-12-14 EP disclosed
CN-105980480-A POLYARYLENE SULFIDE RESIN COMPOSITION 帝人株式会社 2016-09-28 CN disclosed
US-9067900-B2 Diaminophenothiazine compounds, a method for preparing same and uses thereof PHARMA HYDRO DEVELOPMENT—P.H.D. (FR) 2015-06-30 US disclosed
US-8957182-B2 Polyarylene sulfide resin with excellent luminosity and preparation method thereof SK CHEMICALS CO., LTD. (KR) 2015-02-17 US disclosed
CN-104039149-A Boron-containing small molecules ANACOR PHARMACEUTICALS INC 2014-09-10 CN disclosed
US-20140194592-A1 POLYARYLENE SULFIDE RESIN WITH EXCELLENT LUMINOSITY AND PREPARATION METHOD THEREOF SK CHEMICALS CO., LTD. (KR) 2014-07-10 US disclosed
CN-101472585-B Antibacterial compositions BIOTA EUROPE LTD 2013-12-04 CN disclosed
EP-2185531-B1 Diaminophenothiazine compounds, a method for preparing same and uses thereof PHARMA HYDRO DEV P H D (FR) 2012-07-25 EP disclosed
US-20100204215-A1 NOVEL DIAMINOPHENOTHIAZINE COMPOUNDS, A METHOD FOR PREPARING SAME AND USES THEREOF PHARMA HYDRO DEVELOPMENT - P.H.D. (FR) 2010-08-12 US disclosed
EP-2185531-A2 NOVEL DIAMINOPHENOTHIAZINE COMPOUNDS, A METHOD FOR PREPARING SAME AND USES THEREOF Pharma Hydro Development - P.H.D. (FR) 2010-05-19 EP disclosed
WO-2009044054-A2 NOVEL DIAMINOPHENOTHIAZINE COMPOUNDS, A METHOD FOR PREPARING SAME AND USES THEREOF PHARMA HYDRO DEVELOPMENT - P.H.D. (FR) 2009-04-09 WO disclosed
EP-1984332-A2 METHODS FOR TREATING HEPATITIS C PTC Therapeutics, Inc. (US) 2008-10-29 EP disclosed
WO-2007084413-A2 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2007-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100204215-A1 NOVEL DIAMINOPHENOTHIAZINE COMPOUNDS, A METHOD FOR PREPARING SAME AND USES THEREOF AOC1, DDT, DDC LMNA 4600/4885MEN1 2765/4885HTT 2225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.