SCHEMBL30311564

SCHEMBL30311564

NS(=O)(=O)Cc1ccc2c(c1)OCO2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.56
SLC6A4 P31645 2/20 0.54
CYP3A4 P08684 6/20 0.53
SLC6A3 Q01959 3/20 0.53
CYP2D6 P10635 3/20 0.53
SLC6A2 P23975 2/20 0.53
SLC6A1 P30531 1/20 0.53
CMA1 P23946 1/20 0.51
ALDH1A1 P00352 3/20 0.50
CYP1A2 P05177 2/20 0.50
GAA P10253 2/20 0.50
CA12 O43570 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
CYP2C19 P33261 1/20 0.50
HSD17B10 Q99714 1/20 0.50
MAPT P10636 1/20 0.50
MEN1 O00255 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL924831 0.82 ALDH1A1 (0.54) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL6528293 0.81 ALDH1A1 (0.52) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL6529898 0.78 TAAR1 (0.55) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL14380624 0.78 L3MBTL1 (0.60) ALDH1A1GAAMAPTMEN1HTT
SCHEMBL529821 0.77 TAAR1 (0.62) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL29463278 0.75 TAAR1 (0.71) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL57649 0.75 TAAR1 (0.71) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL6510785 0.74 CYP3A4 (0.49) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL108087 0.74 TAAR1 (0.77) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6
SCHEMBL109195 0.74 TAAR1 (0.64) TAAR1SLC6A4CYP3A4SLC6A3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115867133-A Histone acetylation modulators for the treatment and prevention of organ injury 密歇根大学董事会 2023-03-28 CN disclosed