Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30281320 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6828291 | 0.89 | CTSL (0.40) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12164702 | 0.87 | NPC1 (0.37) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12213979 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL13970298 | 0.81 | CTSK (0.51) | ALDH1A1 | |
| SCHEMBL7293004 | 0.81 | CTSK (0.51) | ALDH1A1 | |
| SCHEMBL1696818 | 0.81 | CA1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL20683487 | 0.81 | CA1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL480292 | 0.78 | EPHX1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL284168 | 0.78 | EPHX1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023057882-A1 | COMBINATIONS OF AZALACTAM COMPOUNDS WITH A PD-1 AXIS BINDING ANTAGONIST FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2023-04-13 | — | — | WO | disclosed |