Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 6/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30314643 | 0.89 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL30281320 | 0.87 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL12164702 | 0.85 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL12213979 | 0.84 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL10703068 | 0.79 | TAS1R3 (0.44) | CTSKTAS1R3TAS1R1BIRC2NPC1 | |
| SCHEMBL2455888 | 0.79 | PLA2G2A (0.55) | ALDH1A1MAPTPLA2G2APLA2G5 | |
| SCHEMBL6824840 | 0.79 | PLA2G2A (0.55) | ALDH1A1MAPTPLA2G2APLA2G5 | |
| SCHEMBL1068731 | 0.79 | PLA2G2A (0.55) | ALDH1A1MAPTPLA2G2APLA2G5 | |
| SCHEMBL7293004 | 0.79 | CTSK (0.51) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL13970298 | 0.79 | CTSK (0.51) | CTSLCTSBCTSSCTSKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404718-A2 | INHIBITORS OF MEMAPSIN 2 AND USE THEREOF | Oklahoma Medical Research Foundation (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002053594-A2 | INHIBITORS OF MEMAPSIN 2 AND USE THEREOF | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2002-07-11 | — | — | WO | disclosed |