Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971425 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL971427 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Maleic Acid SCHEMBL10843397 | 0.90 | LMNA (0.48) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Fumaric Acid SCHEMBL10843401 | 0.90 | LMNA (0.48) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL17749334 | 0.87 | LMNA (0.49) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL28303546 | 0.87 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL26668485 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL31381398 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL26668478 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Oxalic Acid SCHEMBL10846796 | 0.86 | HTR2B (0.46) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723741-B1 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE INC (US) | 2016-04-27 | — | — | EP | disclosed |
| US-8962619-B2 | Substituted imidazopyridinyl-aminopyridine compounds | ARQULE, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140073635-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ARQULE, INC. | 2014-03-13 | — | — | US | disclosed |
| WO-2012177844-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20120329791-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ArQuele, Inc. (US) | 2012-12-27 | — | — | US | disclosed |
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2010-08-19 | — | — | US | disclosed |
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2010-08-19 | — | — | US | disclosed |
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2010-08-19 | — | — | US | disclosed |
| EP-2189451-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-05-26 | — | — | EP | disclosed |
| EP-2189451-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-05-26 | — | — | EP | disclosed |
| WO-2007006714-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007006715-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| US-5614518-A | Morpholine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0730593-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014690-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329791-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | SLC6A2 2057/4885SLC6A4 1700/4885SLC6A3 2817/4885 |
| US-20140073635-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | SLC6A2 2057/4885SLC6A4 1700/4885SLC6A3 2817/4885 |
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | HTR4, HTR5A, TPH1 | SLC6A2 417/4885SLC6A4 22/4885SLC6A3 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.