Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | BLM | P54132 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mansouramycin B SCHEMBL29886187 | 0.85 | MAPT (0.36) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| SCHEMBL30317483 | 0.80 | TP53 (0.40) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| Caulibugulone A SCHEMBL2555738 | 0.75 | MAPT (0.63) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| Mansouramycin A SCHEMBL29884737 | 0.72 | — | — | |
| SCHEMBL4540326 | 0.71 | MAPT (0.61) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| SCHEMBL29633340 | 0.71 | MAPT (0.61) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| SCHEMBL29885548 | 0.70 | MAPT (0.44) | MAPTSMN1; SMN2RAB9AHTTALDH1A1 | |
| SCHEMBL2434782 | 0.65 | CYP1A2 (0.39) | ALDH1A1MAOBCYP1A2KMT2ATDP1 | |
| SCHEMBL23235899 | 0.65 | GABRP (0.55) | MAPTSMN1; SMN2BLMTP53CYP3A4 | |
| SCHEMBL30754597 | 0.64 | PTGS2 (0.31) | BLMMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629174-B2 | Cryptic metabolites and method for activating silent biosynthetic gene clusters in actinomycete bacteria | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2023-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629174-B2 | Cryptic metabolites and method for activating silent biosynthetic gene clusters in actinomycete bacteria | FBL, EI24, SUB1 | MAPT 4576/4885SMN1; SMN2 4838/4885BLM 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.