Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27971485 | 0.84 | HRH1 (0.53) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11133065 | 0.84 | KCNH2 (0.52) | CYP3A4CYP2D6CHRM2HTR1AADRA2A | |
| SCHEMBL4001727 | 0.81 | KDM4E (0.47) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27971600 | 0.80 | LOXL2 (0.42) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12853924 | 0.79 | CYP1A2 (0.61) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL443493 | 0.77 | OPRM1 (0.69) | CYP1A2CYP2D6CYP2C9CYP2C19CHRM2 | |
| SCHEMBL12909824 | 0.77 | TAAR1 (0.50) | CYP3A4CYP2D6CHRM2HTR1AADRA2A | |
| SCHEMBL210990 | 0.77 | TAAR1 (0.60) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6637369 | 0.77 | HRH3 (0.60) | LOXL2ALDH1A1TDP1KDM4EGAA | |
| SCHEMBL5179723 | 0.77 | CYP1A2 (0.49) | LOXL2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735586-B2 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI (FR) | 2014-05-27 | — | — | US | claimed |
| EP-2173721-B1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2011-12-28 | — | — | EP | claimed |
| EP-2173747-B1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2011-12-21 | — | — | EP | claimed |
| US-20100261909-A1 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | US | claimed |
| US-20100216988-A1 | Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles | SANOFI-AVENTIS (FR) | 2010-08-26 | — | — | US | claimed |
| EP-2173721-A1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | Sanofi-Aventis (FR) | 2010-04-14 | — | — | EP | claimed |
| EP-2173747-A1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | Sanofi-Aventis (FR) | 2010-04-14 | — | — | EP | claimed |
| CN-101687865-A | A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles | SANOFI AVENTIS | 2010-03-31 | — | — | CN | claimed |
| CN-101687815-A | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI AVENTIS | 2010-03-31 | — | — | CN | claimed |
| WO-2009000413-A1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI-AVENTIS (FR) | 2008-12-31 | — | — | WO | claimed |
| WO-2009000412-A1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI AVENTIS (FR) | 2008-12-31 | — | — | WO | claimed |
| US-20020025477-A1 | Non-aqueous electrolytic solution and secondary battery containing same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-02-28 | — | — | US | claimed |
| EP-1172878-A2 | Non-aqueous electrolytic solution and secondary battery containing same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-01-16 | — | — | EP | claimed |
| US-4402843-A | Viscosity index improvers with dispersant properties prepared by reaction of lithiated hydrogenated copolymers with 4-substituted aminopyridines | PHILLIPS PETROLEUM COMPANY (US) | 1983-09-06 | — | — | US | claimed |
| EP-3279996-B1 | NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY | ASAHI CHEMICAL IND (JP) | 2018-12-26 | — | — | EP | disclosed |
| US-8735586-B2 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-2173721-B1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2011-12-28 | — | — | EP | disclosed |
| US-20020025477-A1 | Non-aqueous electrolytic solution and secondary battery containing same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-02-28 | — | — | US | disclosed |
| EP-1172878-A2 | Non-aqueous electrolytic solution and secondary battery containing same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-4402843-A | Viscosity index improvers with dispersant properties prepared by reaction of lithiated hydrogenated copolymers with 4-substituted aminopyridines | PHILLIPS PETROLEUM COMPANY (US) | 1983-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261909-A1 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | AZI2, NISCH, UQCRB | LOXL2 4605/4885CYP1A2 20/4885CYP3A4 91/4885 |
| US-20100216988-A1 | Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles | AZI2, NIT2, NISCH | LOXL2 4792/4885CYP1A2 92/4885CYP3A4 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.