Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.75 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.75 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.75 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.75 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.75 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.75 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.75 |
| ▸ | BCHE | P06276 | 5/20 | 0.68 |
| ▸ | HTR6 | P50406 | 13/20 | 0.67 |
| ▸ | HRH1 | P35367 | 12/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.67 |
| ▸ | HTR2C | P28335 | 4/20 | 0.67 |
| ▸ | HTR7 | P34969 | 4/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225705 | 0.94 | BCHE (0.66) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL2174231 | 0.93 | GRIN1 (0.71) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL3229857 | 0.92 | GRIN2D (0.64) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL13654632 | 0.91 | GRIN2D (0.62) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL1225397 | 0.89 | BCHE (0.68) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL167305 | 0.89 | HTR6 (0.69) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL168755 | 0.89 | HRH1 (0.69) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12480534 | 0.89 | GRIN1 (0.63) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL8041273 | 0.89 | BCHE (0.68) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL13834422 | 0.88 | GRIN1 (0.65) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907097-B2 | Pyrido[4,3-b]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20110039825-A1 | LIGANDS OF ALPHA-ADRENOCEPTORS, DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THEIR USE | ALLA CHEM, LLC (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039825-A1 | LIGANDS OF ALPHA-ADRENOCEPTORS, DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THEIR USE | ALLA CHEM, LLC (US) | 2011-02-17 | — | — | US | disclosed |
| EP-2236511-A2 | LIGANDS OF ALPHA-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. | 2010-08-26 | — | — | US | disclosed |
| WO-2009082268-A2 | LIGANDS OF α-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039825-A1 | LIGANDS OF ALPHA-ADRENOCEPTORS, DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THEIR USE | ADRB3, ADRA2C, ADRB2 | GRIN1 425/4885GRIN2A 594/4885GRIN2B 522/4885 |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | GRIN1 95/4885GRIN2A 27/4885GRIN2B 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.