Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25792163 | 1.00 | LMNA (0.42) | LMNAALDH1A1GAAPTGS2VCAM1 | |
| SCHEMBL25792164 | 0.84 | PTGS2 (0.43) | LMNAALDH1A1GAAPTGS2SMN1; SMN2 | |
| SCHEMBL30320437 | 0.84 | PTGS2 (0.43) | LMNAALDH1A1GAAPTGS2SMN1; SMN2 | |
| SCHEMBL25792162 | 0.81 | SCN9A (0.39) | LMNAALDH1A1GAAPTGS2SCN9A | |
| SCHEMBL25791924 | 0.78 | APOBEC3G (0.46) | LMNAALDH1A1PTGS2MEN1RAB9A | |
| SCHEMBL30319724 | 0.78 | GABRA1 (0.41) | PTGS2SCN9AAR | |
| SCHEMBL23909950 | 0.76 | LMNA (0.49) | LMNAALDH1A1GAAPTGS2VCAM1 | |
| SCHEMBL23910067 | 0.73 | BCHE (0.58) | LMNAALDH1A1GAAVCAM1AR | |
| SCHEMBL21071965 | 0.69 | ALDH1A1 (0.52) | LMNAALDH1A1GAAPTGS2VCAM1 | |
| SCHEMBL25975183 | 0.68 | SCN9A (0.45) | LMNAGAAPTGS2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |