Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24111414 | 1.00 | GPR119 (0.46) | GPR119JAK2JAK1RORCGRM5 | |
| SCHEMBL30324497 | 0.84 | RORC (0.42) | GPR119JAK2JAK1RORC | |
| SCHEMBL23705964 | 0.80 | GPR119 (0.49) | GPR119JAK2JAK1GRM5EGLN2 | |
| SCHEMBL17729471 | 0.77 | MAPT (0.52) | GPR119RORC | |
| SCHEMBL24111557 | 0.77 | GPR119 (0.47) | GPR119JAK2JAK1GRM5EGLN2 | |
| SCHEMBL30835998 | 0.76 | SYK (0.43) | GPR119RORCGRM5 | |
| SCHEMBL17541957 | 0.75 | RORC (0.49) | RORC | |
| SCHEMBL20570727 | 0.75 | RORC (0.49) | GPR119RORC | |
| SCHEMBL26105375 | 0.74 | RORC (0.43) | GPR119JAK2JAK1RORC | |
| SCHEMBL23802575 | 0.74 | GPR119 (0.49) | GPR119RORCGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4164654-A1 | RIPK1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |