Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377105 | 0.94 | ALDH1A1 (0.49) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL2189008 | 0.89 | LMNA (0.49) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL3378326 | 0.87 | KCNA5 (0.52) | ALDH1A1LMNAKMT2AKCNA5TP53 | |
| SCHEMBL3377152 | 0.82 | LMNA (0.60) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL302059 | 0.82 | LMNA (0.52) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL302652 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL2213840 | 0.78 | TSHR (0.53) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL2188004 | 0.77 | ALDH1A1 (0.65) | ALDH1A1LMNAKMT2AKCNA5SMN1; SMN2 | |
| SCHEMBL3374237 | 0.76 | HPGD (0.52) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL3379849 | 0.74 | MAPT (0.59) | ALDH1A1LMNAKMT2ATSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |