Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3022626 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL2616850 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL4896898 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL7310655 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL2132706 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL3027865 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL4004075 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL3373723 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL4604695 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL4734326 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | ALDH1A1 348/4885HPGD 824/4885KDM4E 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.