Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217181 | 0.90 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL6324064 | 0.86 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL2449511 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1MAPTKCNJ1 | |
| SCHEMBL27354737 | 0.81 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL3035932 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4578043 | 0.80 | IRAK4 (0.49) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL481566 | 0.79 | EGLN1 (0.40) | MAPTMEN1KMT2AGABRA1GABRG2 | |
| SCHEMBL3022374 | 0.79 | HRH4 (0.41) | SMN1; SMN2MAPTMEN1KMT2AGABRA1 | |
| SCHEMBL30707882 | 0.79 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3055116 | 0.79 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | ALDH1A1 348/4885SMN1; SMN2 3196/4885L3MBTL1 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.