Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 13/20 | 0.57 |
| ▸ | CNR1 | P21554 | 8/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946747 | 0.90 | CNR2 (0.67) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL3030328 | 0.86 | CNR2 (0.55) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL3950873 | 0.84 | CNR2 (0.57) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL3948637 | 0.83 | CNR2 (0.60) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL3035441 | 0.83 | HTR1A (0.59) | CNR2CNR1HTR1AHTR1BMEN1 | |
| SCHEMBL27293376 | 0.77 | CNR2 (0.55) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL25018133 | 0.75 | TYR (0.50) | CNR2CNR1MEN1KMT2ATSHR | |
| SCHEMBL7754630 | 0.75 | KMT2A (0.54) | CNR2CNR1HTR1AHTR1BMEN1 | |
| SCHEMBL7751114 | 0.75 | KMT2A (0.54) | CNR2CNR1HTR1AHTR1BMEN1 | |
| SCHEMBL7751086 | 0.75 | KMT2A (0.54) | CNR2CNR1HTR1AHTR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100215594-A1 | Tyrosinase Inhibitors | MERCK PATENT GMBH (DE) | 2010-08-26 | — | — | US | claimed |
| US-20100215594-A1 | Tyrosinase Inhibitors | MERCK PATENT GMBH (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100215594-A1 | Tyrosinase Inhibitors | MERCK PATENT GMBH (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100215594-A1 | Tyrosinase Inhibitors | MERCK PATENT GMBH (DE) | 2010-08-26 | — | — | US | disclosed |
| WO-2009021589-A1 | TYROSINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100215594-A1 | Tyrosinase Inhibitors | TYR, TH, COMT | CNR2 4435/4885CNR1 4099/4885HTR1A 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.