SCHEMBL3035803

SCHEMBL3035803

O=Cc1c([N+](=O)[O-])ccc(O)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH5A1 P51649 1/20 0.53
ABAT P80404 1/20 0.53
ERN1 O75460 3/20 0.49
XDH P47989 1/20 0.49
TP53 P04637 2/20 0.47
HPGD P15428 2/20 0.47
TSHR P16473 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
CYP3A4 P08684 1/20 0.47
HIF1A Q16665 1/20 0.47
CTSB P07858 1/20 0.47
GPR35 Q9HC97 3/20 0.45
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 2/20 0.44
MAPK1 P28482 2/20 0.44
ALDH1A1 P00352 1/20 0.44
ALOX15 P16050 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16838211 0.88 ERN1 (0.56) ALDH5A1ABATERN1XDHTP53
SCHEMBL31448585 0.85 ERN1 (0.53) ALDH5A1ABATERN1XDHTP53
SCHEMBL31448565 0.85 ERN1 (0.53) ALDH5A1ABATERN1XDHTP53
SCHEMBL16838198 0.83 GPR35 (0.52) ALDH5A1ABATERN1XDHTP53
SCHEMBL16838217 0.79 GPR35 (0.52) ALDH5A1ABATERN1XDHTP53
SCHEMBL8655232 0.78 ALDH5A1 (0.50) ALDH5A1ABATERN1XDHTP53
SCHEMBL15811523 0.78 ALDH5A1 (0.50) ALDH5A1ABATERN1XDHTP53
SCHEMBL4888730 0.78 ERN1 (0.57) ERN1HPGDCYP3A4ALDH1A1ALOX15
SCHEMBL10501311 0.78 ERN1 (0.57) ERN1HPGDCYP3A4ALDH1A1ALOX15
SCHEMBL351534 0.77 GPR35 (0.60) ALDH5A1ABATERN1TP53HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003031-B Amphiphilic molecule containing o-nitrobenzyl ester photodegradation group and synthetic method thereof 大连理工大学 2020-06-02 CN disclosed
US-7718598-B1 Auxiliary for amide bond formation THE UNIVERSITY OF QUEENSLAND (AU) 2010-05-18 US disclosed
EP-1115739-B1 AUXILIARY FOR AMIDE BOND FORMATION UNIV QUEENSLAND (AU) 2009-04-29 EP disclosed
EP-1115739-A4 AUXILIARY FOR AMIDE BOND FORMATION UNIV QUEENSLAND (AU) 2004-10-27 EP disclosed
EP-1115739-A1 AUXILIARY FOR AMIDE BOND FORMATION THE UNIVERSITY OF QUEENSLAND (AU) 2001-07-18 EP disclosed
WO-2000018789-A1 AUXILIARY FOR AMIDE BOND FORMATION THE UNIVERSITY OF QUEENSLAND (AU) 2000-04-06 WO disclosed