Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18487096 | 0.97 | MEN1 (0.46) | MAPTNR3C1KMT2AMEN1MCL1 | |
| SCHEMBL3381042 | 0.94 | MEN1 (0.48) | MAPTKMT2AMEN1MCL1LMNA | |
| SCHEMBL3380874 | 0.88 | NR3C1 (0.54) | MAPTNR3C1KMT2AMEN1KEAP1 | |
| SCHEMBL3377911 | 0.85 | MAPT (0.54) | MAPTNR3C1KMT2AMEN1MCL1 | |
| SCHEMBL312209 | 0.81 | AVPR2 (0.41) | MAPTKMT2AMEN1MCL1PTGES | |
| SCHEMBL303671 | 0.80 | MAPT (0.43) | MAPTKMT2AMEN1MCL1PTGES | |
| SCHEMBL302950 | 0.79 | NR3C1 (0.55) | MAPTNR3C1KEAP1NFE2L2MCL1 | |
| SCHEMBL303293 | 0.79 | GAA (0.63) | MAPTNR3C1KMT2AMEN1LMNA | |
| SCHEMBL301986 | 0.79 | NAMPT (0.51) | MAPTKEAP1NFE2L2MCL1NR1I2 | |
| SCHEMBL1722971 | 0.77 | MEN1 (0.51) | KMT2AMEN1PTGESALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |