Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462640 | 0.89 | MAPT (0.54) | KDM4ECRHBPCRHR2KIF11GRIA1 | |
| SCHEMBL7030752 | 0.83 | KDM4E (0.60) | KDM4ECRHBPCRHR2KIF11GRIA1 | |
| SCHEMBL7033184 | 0.83 | KIF11 (0.58) | KDM4ECRHBPCRHR2KIF11CES1 | |
| SCHEMBL20838849 | 0.81 | GRIA1 (0.57) | KDM4ECRHBPCRHR2GRIA1CACNG8 | |
| SCHEMBL18190756 | 0.79 | GRIA1 (0.49) | KDM4ECRHBPCRHR2GRIA1CACNG8 | |
| SCHEMBL22425116 | 0.78 | EPHX2 (0.66) | KDM4EKMT2APOLBL3MBTL1MAPT | |
| SCHEMBL3780885 | 0.75 | MAPT (0.53) | KDM4ECRHBPCRHR2KIF11CES1 | |
| SCHEMBL29456231 | 0.75 | MAPT (0.53) | KDM4ECRHBPCRHR2KIF11CES1 | |
| SCHEMBL18193473 | 0.75 | PDE3B (0.48) | KDM4EGRIA1CACNG8GAAKMT2A | |
| SCHEMBL2107333 | 0.75 | HSD17B10 (0.66) | KDM4EKMT2APDE3BPDE3APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790169-B | Cyanopyrrolidine derivatives having activity as USP30 inhibitors | 特殊治疗有限公司 | 2022-03-29 | — | — | CN | disclosed |
| EP-3519412-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-12-01 | — | — | EP | disclosed |
| US-11084821-B2 | Cyanopyrrolidine derivatives with activity as inhibitors of USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2021-08-10 | — | — | US | disclosed |
| US-20200199126-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2020-06-25 | — | — | US | disclosed |
| US-20100216821-A1 | Benzimidazoles With A Hetero Spiro-Decane Residue As NPY-Y5 Antagonists | BARTON NICHOLAS PAUL | 2010-08-26 | — | — | US | disclosed |
| US-20100216821-A1 | Benzimidazoles With A Hetero Spiro-Decane Residue As NPY-Y5 Antagonists | BARTON NICHOLAS PAUL | 2010-08-26 | — | — | US | disclosed |
| US-20100216821-A1 | Benzimidazoles With A Hetero Spiro-Decane Residue As NPY-Y5 Antagonists | BARTON NICHOLAS PAUL | 2010-08-26 | — | — | US | disclosed |
| WO-2008129007-A1 | BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |
| US-20080076810-A1 | Benzoureas Having Anti-Diabetic Activity | MERCK SHARP & DOHME CORP. | 2008-03-27 | — | — | US | disclosed |
| US-20080076810-A1 | Benzoureas Having Anti-Diabetic Activity | MERCK SHARP & DOHME CORP. | 2008-03-27 | — | — | US | disclosed |
| US-20080076810-A1 | Benzoureas Having Anti-Diabetic Activity | MERCK SHARP & DOHME CORP. | 2008-03-27 | — | — | US | disclosed |
| EP-1753423-A2 | BENZOUREAS HAVING ANTI-DIABETIC ACTIVITY | Merck & Co., Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2006022954-A2 | BENZOUREAS HAVING ANTI-DIABETIC ACTIVITY | MERCK & CO., INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199126-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | USP30, USP1, USP28 | KDM4E 1215/4885CRHBP 1337/4885CRHR2 4079/4885 |
| US-20080076810-A1 | Benzoureas Having Anti-Diabetic Activity | PPARD, PPARG, GPR119 | KDM4E 1266/4885CRHBP 3727/4885CRHR2 2478/4885 |
| US-11084821-B2 | Cyanopyrrolidine derivatives with activity as inhibitors of USP30 | USP30, USP39, USP28 | KDM4E 1135/4885CRHBP 1236/4885CRHR2 4012/4885 |
| US-20100216821-A1 | Benzimidazoles With A Hetero Spiro-Decane Residue As NPY-Y5 Antagonists | NPY5R, NPY4R, NPY1R | KDM4E 1611/4885CRHBP 486/4885CRHR2 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.