Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.45 |
| ▸ | ITGAV | P06756 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534236 | 0.71 | CA1 (0.40) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL8684279 | 0.69 | MAPT (0.70) | MAPTITGB3ITGAVSMN1; SMN2 | |
| SCHEMBL8534686 | 0.69 | FEN1 (0.44) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL30153520 | 0.68 | MMP2 (0.49) | ITGAVPTGS2MMP1MMP2MMP9 | |
| SCHEMBL31027970 | 0.68 | MMP2 (0.49) | ITGAVPTGS2MMP1MMP2MMP9 | |
| SCHEMBL27725613 | 0.68 | MMP2 (0.49) | MAPTLMNASMN1; SMN2PTGS2MMP1 | |
| SCHEMBL23795533 | 0.67 | MAPT (0.50) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL14186058 | 0.67 | MAPT (0.50) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL8532235 | 0.67 | CA1 (0.40) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL8532987 | 0.67 | ITGB3 (0.38) | MAPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4412655-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THE TREATMENT, PREVENTION, OR MANAGEMENT OF HYPERPROLIFERATIVE DISORDER | Vincerx Pharma GmbH (DE) | 2024-08-14 | — | — | EP | disclosed |
| WO-2023057812-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THE TREATMENT, PREVENTION, OR MANAGEMENT OF HYPERPROLIFERATIVE DISORDER | VINCERX PHARMA GMBH (DE) | 2023-04-13 | — | — | WO | disclosed |