SCHEMBL30360768

SCHEMBL30360768

N#Cc1ccc(Oc2cccc(C#N)c2C#N)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
POLB P06746 2/20 0.51
GAA P10253 1/20 0.51
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49
PDE4C Q08493 1/20 0.49
PDE4D Q08499 1/20 0.49
SLC6A4 P31645 1/20 0.48
TLR8 Q9NR97 2/20 0.43
CYP19A1 P11511 1/20 0.42
CYP11B1 P15538 3/20 0.40
PARP15 Q460N3 1/20 0.40
PARP10 Q53GL7 1/20 0.40
PARP2 Q9UGN5 1/20 0.40
CYP11B2 P19099 1/20 0.40
AR P10275 2/20 0.40
MAPT P10636 2/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20511067 1.00 KDM4E (0.54) KDM4ESMN1; SMN2POLBGAAPDE4A
SCHEMBL9745478 0.86 SMN1; SMN2 (0.58) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL9359794 0.86 KDM4E (0.54) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL9745662 0.86 SMN1; SMN2 (0.58) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL669346 0.86 SMN1; SMN2 (0.57) KDM4ESMN1; SMN2POLBGAAAR
SCHEMBL1362882 0.85 SMN1; SMN2 (0.53) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL8975487 0.85 POLB (0.73) KDM4ESMN1; SMN2POLBGAASLC6A4
SCHEMBL5012743 0.85 SMN1; SMN2 (0.53) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL9746057 0.85 KDM4E (0.53) KDM4ESMN1; SMN2POLBGAATLR8
SCHEMBL31456559 0.85 SMN1; SMN2 (0.53) KDM4ESMN1; SMN2POLBGAATLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110461814-B Resin blends, prepregs and articles containing a phthalonitrile reactive diluent and a bisphthalonitrile resin 3M创新有限公司 2023-04-14 CN disclosed