Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.79 |
| ▸ | RAB9A | P51151 | 8/20 | 0.79 |
| ▸ | CASP3 | P42574 | 1/20 | 0.79 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.79 |
| ▸ | PLAU | P00749 | 5/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | PLG | P00747 | 1/20 | 0.61 |
| ▸ | PLAT | P00750 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788361 | 0.88 | NPC1 (1.00) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL674669 | 0.88 | NPC1 (0.86) | NPC1RAB9ACASP3SENP7HDAC8 | |
| SCHEMBL3454483 | 0.87 | NPC1 (0.77) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL15031541 | 0.84 | NPC1 (0.76) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL10839189 | 0.83 | CA1 (0.70) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL15580882 | 0.83 | NPC1 (0.74) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL5016280 | 0.82 | PLAU (0.75) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL3035716 | 0.82 | PLAU (0.74) | NPC1RAB9APLAUSMN1; SMN2TP53 | |
| SCHEMBL6799157 | 0.81 | RAB9A (1.00) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL3036973 | 0.81 | MEN1 (0.61) | NPC1RAB9ACASP3SENP7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | claimed |
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | BRDT, AADAC, ACIN1 | NPC1 2497/4885RAB9A 4531/4885CASP3 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.