Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.77 |
| ▸ | RAB9A | P51151 | 7/20 | 0.77 |
| ▸ | CASP3 | P42574 | 2/20 | 0.77 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.77 |
| ▸ | PLAU | P00749 | 12/20 | 0.75 |
| ▸ | PLAT | P00750 | 4/20 | 0.72 |
| ▸ | PLG | P00747 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036351 | 0.87 | NPC1 (0.79) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL3788361 | 0.87 | NPC1 (1.00) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL15412987 | 0.86 | NPC1 (0.68) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL15580882 | 0.84 | NPC1 (0.74) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL15031541 | 0.83 | NPC1 (0.76) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL28013893 | 0.81 | PLAU (0.74) | PLAUPLATPLGF2KLKB1 | |
| SCHEMBL21446854 | 0.81 | PLAU (0.79) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL5016280 | 0.81 | PLAU (0.75) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL6799157 | 0.80 | RAB9A (1.00) | NPC1RAB9ACASP3SENP7PLAU | |
| SCHEMBL2917029 | 0.78 | NPC1 (0.82) | NPC1RAB9ACASP3SENP7PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |