Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL608749 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA4MEN1KMT2APOLB | |
| SCHEMBL30499138 | 0.81 | EGFR (0.33) | MEN1KMT2APOLB | |
| SCHEMBL2147358 | 0.81 | EGFR (0.33) | MEN1KMT2APOLB | |
| SCHEMBL26170410 | 0.81 | HTT (0.35) | KMT2A | |
| SCHEMBL189068 | 0.80 | GRM5 (0.44) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL29812510 | 0.80 | PLAU (0.42) | POLBALDH1A1KDM4E | |
| SCHEMBL17593337 | 0.80 | PLAU (0.42) | POLBALDH1A1KDM4E | |
| SCHEMBL28850186 | 0.79 | KMT2A (0.39) | MEN1KMT2APOLB | |
| SCHEMBL30866857 | 0.79 | MET (0.41) | — | |
| SCHEMBL21512505 | 0.79 | MET (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405051-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023046806-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |