Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CD4 | P01730 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29266679 | 1.00 | THRA (0.34) | THRATHRBTSHRMEN1KMT2A | |
| SCHEMBL30368321 | 0.95 | KDM2B (0.32) | — | |
| SCHEMBL30368362 | 0.82 | MEN1 (0.33) | TSHRMEN1KMT2AMCOLN3 | |
| SCHEMBL30368062 | 0.80 | ALDH1A1 (0.38) | THRBKMT2AMCOLN3 | |
| SCHEMBL30958005 | 0.78 | AR (0.40) | MEN1KMT2AMAOAMAOB | |
| SCHEMBL29266632 | 0.78 | AR (0.40) | MEN1KMT2AMAOAMAOB | |
| SCHEMBL30301734 | 0.76 | ALB (0.37) | MEN1KMT2AMAOAMAOBELANE | |
| SCHEMBL30970483 | 0.73 | CCNA2 (0.34) | CCNA2CDK2CDK1CCNB1 | |
| SCHEMBL30970487 | 0.73 | CCNA2 (0.34) | CCNA2CDK2CDK1CCNB1 | |
| SCHEMBL25260408 | 0.71 | THRA (0.41) | THRATHRBCCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118317954-A | Indoline as PROTAC compound | 奈奥芬莱有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-118317949-A | Isoindolines as PMS2 inhibitors | 奈奥芬莱有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-115996907-A | Inhibitors of MLH1 and/or PMS2 for cancer treatment | 奈奥芬莱有限公司 | 2023-04-21 | — | — | CN | disclosed |