Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.78 |
| ▸ | KCNA3 | P22001 | 5/20 | 0.78 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68111 | 0.93 | KCNN4 (0.68) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL3042508 | 0.88 | KCNN4 (1.00) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL3042308 | 0.84 | KCNA3 (1.00) | KCNN4KCNA3NOTUMALDH1A1USP2 | |
| SCHEMBL3044124 | 0.83 | KCNN4 (0.68) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL3034521 | 0.81 | KCNN4 (0.61) | KCNN4KCNA3NOTUMALDH1A1HPGD | |
| SCHEMBL7003872 | 0.78 | NOTUM (0.73) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL842907 | 0.77 | HPGD (0.64) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL1495885 | 0.76 | ALDH1A1 (0.58) | HTTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL1048074 | 0.74 | NOTUM (1.00) | KCNN4KCNA3NOTUMHTTALDH1A1 | |
| SCHEMBL30003296 | 0.74 | NOTUM (1.00) | KCNN4KCNA3NOTUMHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216772-A1 | Novel Phenantridine Analogues and Uses Thereof | 4SC AG (DE) | 2010-08-26 | — | — | US | disclosed |
| EP-1740548-A1 | NOVEL PHENANTRIDINE ANALOGUES AND THEIR USES AS INHIBITORS OF HYPERPROLIFERATION OF T CELLS AND/OR KERATINOCYTES | 4SC AG (DE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105752-A1 | NOVEL PHENANTRIDINE ANALOGUES AND THEIR USES AS INHIBITORS OF HYPERPROLIFERATION OF T CELLS AND/OR KERATINOCYTES | 4SC AG (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216772-A1 | Novel Phenantridine Analogues and Uses Thereof | P2RX4, P2RX5, CLIC4 | KCNN4 50/4885KCNA3 52/4885NOTUM 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.