SCHEMBL30379290

SCHEMBL30379290

CCn1c(=O)cc(C)c2cc(C#N)ccc21

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.49
BRPF1 P55201 3/20 0.47
BRD1 O95696 2/20 0.47
POLB P06746 1/20 0.44
HSD17B10 Q99714 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PTGER4 P35408 1/20 0.43
LMNA P02545 1/20 0.42
RORC P51449 5/20 0.42
BRD4 O60885 1/20 0.41
BRD9 Q9H8M2 1/20 0.41
BRPF3 Q9ULD4 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
IDH1 O75874 1/20 0.41
CYP11B2 P19099 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26091169 1.00 KDM4E (0.49) KDM4EBRPF1BRD1POLBHSD17B10
SCHEMBL4555901 0.88 KDM4E (0.49) KDM4EBRPF1BRD1LMNABRD4
SCHEMBL21076080 0.81 RORC (0.52) KDM4EHSD17B10PTGER4RORCMEN1
SCHEMBL30379731 0.80 BRPF1 (0.63) KDM4EBRPF1BRD1BRD4BRD9
SCHEMBL26090101 0.80 BRPF1 (0.63) KDM4EBRPF1BRD1BRD4BRD9
SCHEMBL5984776 0.80 KDM4E (0.64) KDM4EPOLBHSD17B10L3MBTL1LMNA
SCHEMBL3781733 0.77 KDM4E (0.47) KDM4EPOLBHSD17B10L3MBTL1LMNA
SCHEMBL17505195 0.77 KDM4E (0.55) KDM4EBRPF1POLBHSD17B10L3MBTL1
SCHEMBL97588 0.75 PTGER4 (0.54) PTGER4RORC
SCHEMBL30367071 0.74 MEN1 (0.69) KDM4EHSD17B10LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023067192-A1 METHODS FOR IMPROVING ABIOTIC STRESS RESISTANCE CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2023-04-27 WO disclosed