Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.42 |
| ▸ | BRD1 | O95696 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26091169 | 0.88 | KDM4E (0.49) | KDM4ELMNACYP11B2BRPF1BRD1 | |
| SCHEMBL30379290 | 0.88 | KDM4E (0.49) | KDM4ELMNACYP11B2BRPF1BRD1 | |
| SCHEMBL4787783 | 0.85 | ALDH1A1 (0.44) | KDM4ECHEK1BRPF1BRD1MEN1 | |
| SCHEMBL4789761 | 0.82 | KDM4E (0.39) | KDM4ECHEK1LMNABRPF1BRD1 | |
| SCHEMBL21076085 | 0.81 | PTGER4 (0.48) | CYP11B2CYP11B1ACSS2 | |
| SCHEMBL11099755 | 0.77 | KDM4E (0.50) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL12002162 | 0.75 | KDM4E (0.56) | KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL17066941 | 0.74 | MEN1 (0.69) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL30367071 | 0.74 | MEN1 (0.69) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL21599721 | 0.74 | PTGER4 (0.59) | KDM4ELMNAMEN1KMT2AACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121702-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008071961-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |