Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.33 |
| ▸ | RELA | Q04206 | 3/20 | 0.33 |
| ▸ | JUN | P05412 | 2/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185426 | 0.85 | KEAP1 (0.42) | SMN1; SMN2KDM4EALDH1A1TDP1RAB9A | |
| SCHEMBL17084210 | 0.83 | POLB (0.34) | SMN1; SMN2POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL30414460 | 0.82 | POLB (0.40) | SMN1; SMN2POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL27185691 | 0.81 | MAPT (0.38) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL29784427 | 0.81 | MAPT (0.38) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL30326095 | 0.75 | RAB9A (0.36) | SMN1; SMN2POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL9928617 | 0.72 | AGBL2 (0.39) | SMN1; SMN2KDM4ECYP1A2RAB9ANPC1 | |
| SCHEMBL23326783 | 0.72 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL19950148 | 0.71 | NPC1 (0.34) | SMN1; SMN2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL31309056 | 0.71 | MAOB (0.38) | SMN1; SMN2KDM4ECYP1A2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115989224-B | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-116157154-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-05-23 | — | — | CN | disclosed |
| EP-4178620-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-05-17 | — | — | EP | disclosed |
| CN-115989224-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-04-18 | — | — | CN | disclosed |