Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.54 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TYR | P14679 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6044777 | 1.00 | ALOX15 (0.54) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL14879742 | 0.84 | ALOX15 (0.43) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL396749 | 0.82 | ALDH1A1 (0.61) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL22140388 | 0.79 | ALOX15 (0.39) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL15301192 | 0.79 | CASP1 (0.41) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL12732773 | 0.79 | ESRRA (0.49) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL30874683 | 0.78 | PTGDR2 (0.46) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9248443 | 0.78 | PTGDR2 (0.46) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL6510666 | 0.78 | ALDH1A1 (0.67) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL19457567 | 0.78 | ALOX15 (0.38) | ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577525-A1 | PYRIDAZINONE COMPOUNDS WHICH MODULATE MUTANT PROTEINS FOR TREATING RESPIRATORY DISEASES | The Hospital For Sick Children (CA) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024040350-A1 | PYRIDAZINONE COMPOUNDS WHICH MODULATE MUTANT PROTEINS FOR TREATING RESPIRATORY DISEASES | THE HOSPITAL FOR SICK CHILDREN (CA) | 2024-02-29 | — | — | WO | disclosed |
| CN-116157387-A | Isoquinoline compounds and their use in the treatment of AhR imbalance | 德玛万科学有限公司 | 2023-05-23 | — | — | CN | disclosed |