Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30392549 | 0.92 | PRKACA (0.45) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL25520813 | 0.76 | PDGFRA (0.39) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL26135594 | 0.74 | ALDH1A1 (0.44) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL8558598 | 0.74 | IDO1 (0.53) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL9722001 | 0.69 | IDO1 (0.55) | ALDH1A1LMNACHRNA7MEN1KMT2A | |
| SCHEMBL19014758 | 0.67 | LMNA (0.48) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL29014606 | 0.67 | ALDH1A1 (0.47) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL19014677 | 0.67 | LMNA (0.48) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL21840899 | 0.67 | TRPM8 (0.49) | ALDH1A1LMNACHRNA7GAAMEN1 | |
| SCHEMBL19014832 | 0.67 | LMNA (0.48) | ALDH1A1LMNACHRNA7GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423069-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023077046-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2023-05-04 | — | — | WO | disclosed |