Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23173797 | 0.94 | CRBN (0.56) | CRBNDDB1USP30ALDH1A1TSHR | |
| SCHEMBL23123218 | 0.88 | CRBN (0.49) | CRBNDDB1USP30EPHX2 | |
| SCHEMBL30009143 | 0.88 | CRBN (0.49) | CRBNDDB1USP30EPHX2 | |
| SCHEMBL30874149 | 0.83 | ACACB (0.45) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL21427524 | 0.83 | GABRD (0.61) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL30392489 | 0.83 | GABRD (0.61) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL27148853 | 0.83 | CRBN (0.46) | CRBNDDB1USP30EPHX2 | |
| SCHEMBL26509089 | 0.83 | MEN1 (0.46) | CRBNDDB1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL30148829 | 0.82 | CRBN (0.42) | CRBNDDB1ALDH1A1TSHRMEN1 | |
| SCHEMBL29265203 | 0.81 | CRBN (0.55) | CRBNDDB1USP30ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |