ADH4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL39255	0.89	3/20
SCHEMBL726395	0.70	3/20
SCHEMBL304406	0.57	3/20
SCHEMBL798471	0.57	3/20
SCHEMBL55195	0.52	3/20
SCHEMBL95389	0.52	3/20
SCHEMBL102600	0.52	3/20
SCHEMBL270650	0.52	3/20
SCHEMBL276848	0.52	3/20
SCHEMBL276871	0.52	3/20
SCHEMBL277587	0.52	3/20
SCHEMBL270100	0.50	3/20
SCHEMBL528874	0.50	3/20
SCHEMBL772457	0.50	3/20
SCHEMBL798497	0.50	3/20
SCHEMBL967215	0.48	3/20
SCHEMBL966676	0.47	3/20
SCHEMBL536191	0.41	3/20
SCHEMBL59918	0.41	3/20
SCHEMBL329469	0.41	3/20

Clinical trials — most relevant to ADH4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis	PHASE4	NOT_YET_RECRUITING
High Dose Vitamin B1 to Reduce Abusive Alcohol Use	PHASE4	COMPLETED
Pharmacogenetics of Nicotine Addiction Treatment	PHASE3	COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
IST Neoadjuvant Abraxane in Newly Diagnosed Breast Cancer	PHASE2	UNKNOWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Pharmacogenetics of Nicotine Metabolism in African-Americans	PHASE1	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
ALDH2 Genetic Testing in East Asian Community	nan	NOT_YET_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Development of an Optimal Micronutrient Reference Range for Adults	nan	COMPLETED
Nutritional Assessment in Patient of Mucopolysaccharide	nan	NOT_YET_RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis	nan	COMPLETED
Environmental & Genetic Influences on Vitamin D Status	nan	COMPLETED
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China	nan	COMPLETED
Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism	nan	RECRUITING
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
ADH1B and ALDH Gene Variants and Lung Cancer Risk	nan	NOT_YET_RECRUITING
Adrenoleukodystrophy National Registry Study	nan	RECRUITING
Mucomyst for Hepatitis C	nan	SUSPENDED
Inflammation in COPD and the Effect of Nicotinamide Riboside	nan	COMPLETED
Optimized Remission in Alcohol-related Liver Cirrhosis	nan	RECRUITING
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases	nan	COMPLETED
Metabolic Availability of Lysine From Barley in Young Adult Men	nan	NOT_YET_RECRUITING
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADH4 binder may also engage these)

Protein	Name	Similarity
O46650	—	1.000	O46650 →
O46649	—	1.000	O46649 →
A0A2U1Q018	—	1.000	A0A2U1Q018 →
Q64563	—	1.000	Q64563 →
Q64415	—	1.000	Q64415 →
P41681	—	1.000	P41681 →
P22797	—	1.000	P22797 →
O57380	—	0.999	O57380 →
P86883	—	0.999	P86883 →
Q9Z2M2	—	0.997	Q9Z2M2 →
P28332	—	0.997	P28332 →
Q5R7Z8	—	0.996	Q5R7Z8 →
P86885	—	0.996	P86885 →
P26325	—	0.996	P26325 →
Q9QYY9	—	0.996	Q9QYY9 →
Q64437	—	0.996	Q64437 →
ADH1C	Alcohol dehydrogenase 1C	0.996	landscape →
Q5XI95	—	0.996	Q5XI95 →
P78870	—	0.995	P78870 →
ADH7	All-trans-retinol dehydrogenase [NAD(+)] ADH7	0.995	landscape →
O97959	—	0.995	O97959 →
A1L4Y2	—	0.995	A1L4Y2 →
P00328	—	0.995	P00328 →
P00329	—	0.994	P00329 →
P41680	—	0.994	P41680 →
A0A2I7G3B3	—	0.994	A0A2I7G3B3 →
P80222	—	0.994	P80222 →
P80468	—	0.994	P80468 →
A0A2I7G3B2	—	0.994	A0A2I7G3B2 →
Q9SK86	—	0.993	Q9SK86 →