Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KDM5C | P41229 | 3/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3039750 | 0.87 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1ACE | |
| Succinic Acid SCHEMBL3039741 | 0.84 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1ACE | |
| Propionic Acid SCHEMBL27782593 | 0.79 | FFAR3 (0.59) | LMNAOR51E2SLC22A6TSHRFFAR3 | |
| Succinic Acid SCHEMBL285626 | 0.76 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL28695489 | 0.75 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1ACE | |
| Hydrogen Peroxide SCHEMBL7056371 | 0.75 | — | — | |
| Succinic Acid SCHEMBL4269130 | 0.75 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1ACE | |
| Succinic Acid SCHEMBL3799615 | 0.75 | — | — | |
| Succinic Acid SCHEMBL21867134 | 0.75 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1ACE | |
| Succinic Acid SCHEMBL829 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1117838-C | Composition of wearing-resistant hydraulic oil and lubricating oil | VANDERBILT CO R T (US) | 2003-08-13 | — | — | CN | claimed |
| CN-1285394-A | Composition of wearing-resistant hydraulic oil and lubricating oil | VANDERBILT CO R T (US) | 2001-02-28 | — | — | CN | claimed |
| CN-1190669-A | Phosphate-based additives for hydraulic fluids and lubricating compositions | VANDERBILT CO R T (US) | 1998-08-19 | — | — | CN | claimed |
| EP-3189125-B1 | LUBRICATING COMPOSITIONS COMPRISING LIQUID ASHLESS ANTIOXIDANT ADDITIVE | VANDERBILT CHEMICALS LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| CN-106604980-B | Liquid ashless antioxidant additives for lubricating compositions | 范德比尔特化学品有限责任公司 | 2020-04-17 | — | — | CN | disclosed |
| EP-3334808-A1 | IMPROVED ANTIOXIDANT COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME | Vanderbilt Chemicals, LLC (US) | 2018-06-20 | — | — | EP | disclosed |
| EP-3334811-A1 | NOVEL ALKYLATED DIPHENYLAMINE DERIVATIVES OF TRIAZOLE AND LUBRICATING COMPOSITIONS CONTAINING THE SAME | Vanderbilt Chemicals, LLC (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9994531-B2 | Antioxidant compositions and lubricating compositions containing the same | VANDERBILT CHEMICALS, LLC (US) | 2018-06-12 | — | — | US | disclosed |
| CN-108026467-A | Improved antioxidant composition and lubricating composition containing the same | 范德比尔特化学品有限责任公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-108026470-A | The lubricating composition of the new alkylation diphenylamine derivatives of triazole and the new alkylation diphenylamine derivatives containing the triazole | 范德比尔特化学品有限责任公司 | 2018-05-11 | — | — | CN | disclosed |
| US-9783759-B2 | Liquid ashless antioxidant additive for lubricating compositions | VANDERBILT CHEMICALS, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| EP-1446465-A1 | IMPROVED ANTIOXIDANT, ANTIWEAR/EXTREME PRESSURE ADDITIVE COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME | R.T. Vanderbilt Company, Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1317520-A4 | LUBRICATING COMPOSITIONS CONTAINING AROMATIZED 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE POLYMERS | VANDERBILT CO R T (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6743759-B2 | METHYLENEBIS(DI-N- BUTYLDITHIOCARBAMATE) AND (B) A DIPHENYLAMINE DERIVATIVE OF TOLUTRIAZOLE OR BENZOTRIAZOLE WHEREIN THE (A):(B) MASS PRECENT RATIO RANGES FROM ABOVE ABOUT 4:1 TO ABOUT 50:1 AND LUBRICATING COMPOSITIONS CONTAINING | R.T. VANDERBILT COMPANY, INC. | 2004-06-01 | — | — | US | disclosed |
| CN-1444641-A | Lubricating compositions containing aromatized 1,2-dihydro-2,2,4-trimethylquinoline polymers | VANDERBILT CO R T (DE) | 2003-09-24 | — | — | CN | disclosed |
| US-20030134753-A1 | Antioxidant, antiwear/extreme pressure additive compositions and lubricating compositons containing the same | R.T. VANDERBILT COMPANY, INC. | 2003-07-17 | — | — | US | disclosed |
| EP-1317520-A1 | LUBRICATING COMPOSITIONS CONTAINING AROMATIZED 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE POLYMERS | R.T. Vanderbilt Company, Inc. (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2003044139-A1 | IMPROVED ANTIOXIDANT, ANTIWEAR/EXTREME PRESSURE ADDITIVE COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME | R.T. VANDERBILT COMPANY, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
| WO-2002014457-A1 | LUBRICATING COMPOSITIONS CONTAINING AROMATIZED 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE POLYMERS | R.T. VANDERBILT COMPANY INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| US-6235686-B1 | N-HETEROCYCLE POLYMERS AS OIL ADDITIVE | R.T. VANDERBILT COMPANY, INC. | 2001-05-22 | — | — | US | disclosed |