Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25239800 | 1.00 | SDHB (0.46) | SDHBMAPTLMNANPSR1KDM4E | |
| SCHEMBL25243394 | 0.80 | KDR (0.44) | LMNANPSR1KDM4ETP53HPGD | |
| SCHEMBL31726565 | 0.80 | KDR (0.44) | LMNANPSR1KDM4ETP53HPGD | |
| SCHEMBL25772948 | 0.78 | ULK1 (0.62) | SDHBNR1H2KDR | |
| SCHEMBL6877899 | 0.77 | MEN1 (0.60) | MAPTLMNANPSR1CYP1A2CYP3A4 | |
| SCHEMBL14643154 | 0.76 | SDHB (0.49) | SDHBLMNANPSR1RAB9AMEN1 | |
| SCHEMBL25204693 | 0.75 | MAPT (0.46) | MAPTNPSR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL25527110 | 0.75 | EGFR (0.47) | MAPTRAB9ACDK1CDK2KDR | |
| SCHEMBL25205981 | 0.74 | CDK2 (0.46) | MAPTNPSR1TP53MAPK1HTT | |
| SCHEMBL16671203 | 0.73 | MEN1 (0.46) | MAPTLMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |