Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416755 | 1.00 | KDM4E (0.37) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL20436661 | 0.94 | KDM4E (0.41) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL30401375 | 0.93 | HTR7 (0.36) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL20400745 | 0.93 | HTR7 (0.36) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL20417125 | 0.92 | ADORA2B (0.38) | PTGDRADORA2BADORA2AADORA1KLKB1 | |
| SCHEMBL30401885 | 0.92 | ADORA2B (0.38) | PTGDRADORA2BADORA2AADORA1KLKB1 | |
| SCHEMBL20416870 | 0.88 | PTGDR (0.38) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL20436654 | 0.88 | ADORA2A (0.39) | PTGDRADORA2BADORA2AADORA1ALOX12 | |
| SCHEMBL30401371 | 0.88 | PTGDR (0.38) | KDM4EPTGDRADORA2BADORA2AADORA1 | |
| SCHEMBL20416788 | 0.88 | ADORA2A (0.36) | PTGDRADORA2BADORA2AADORA1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768859-A | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-110214012-B | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |