Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.48 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.48 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22667213 | 1.00 | CUL4A (0.51) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL27048488 | 0.83 | CES1 (0.41) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL20254407 | 0.81 | ACHE (0.54) | ACHEALDH1A1POLB | |
| SCHEMBL1896345 | 0.79 | CUL4A (0.49) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL27048737 | 0.79 | PARK7 (0.57) | ALDH1A1ALDH3A1IDO1TDO2IDO2 | |
| SCHEMBL11192451 | 0.79 | ALDH3A1 (0.49) | ALDH1A1ALDH3A1ALDH2S100A4CASP3 | |
| SCHEMBL9108120 | 0.78 | CUL4A (0.51) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL28431766 | 0.78 | CUL4A (0.45) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL2304466 | 0.78 | ALDH1A1 (0.54) | CUL4AACHECES1ALDH1A1ALDH3A1 | |
| SCHEMBL1895648 | 0.77 | CUL4A (0.53) | CUL4AACHECES1ALDH1A1ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111433195-B | Pyridone derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |