SCHEMBL30405671

SCHEMBL30405671

CC1(C)Cn2nc(-c3cccnc3)cc2CO1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.41
CYP2E1 P05181 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2B6 P20813 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP3A4 P08684 4/20 0.39
CYP11B1 P15538 4/20 0.38
CYP11B2 P19099 4/20 0.38
ALK Q9UM73 1/20 0.38
METAP2 P50579 1/20 0.37
SIRT3 Q9NTG7 1/20 0.37
CYP19A1 P11511 1/20 0.37
BACE1 P56817 2/20 0.37
CTSD P07339 1/20 0.37
USP8 P40818 1/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 2/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29514213 0.77 PGR (0.36) ALDH1A1
SCHEMBL30403702 0.76 CYP2C9 (0.46) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19
SCHEMBL30605084 0.71 CSNK1D (0.48)
SCHEMBL30405582 0.70 CYP2A6 (0.38) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19
SCHEMBL29514172 0.68 CSNK1A1 (0.39) ALDH1A1
SCHEMBL16682846 0.68 PDCD1 (0.55) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19
SCHEMBL24892502 0.66 AAK1 (0.49) CYP11B1CYP11B2ALDH1A1
SCHEMBL30405703 0.65 CYP2A6 (0.42) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19
SCHEMBL12279439 0.63 CYP2A6 (0.54) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19
SCHEMBL2689845 0.63 CYP2A6 (0.54) CYP2A6CYP2E1CYP2C9CYP2B6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116171280-A Casein kinase 1 delta modulators 詹森药业有限公司 2023-05-26 CN disclosed