Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | HPN | P05981 | 3/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19608948 | 0.85 | KDM4E (0.53) | DAOMAPTITKTDP1KDM4E | |
| SCHEMBL30409436 | 0.85 | KDM4E (0.53) | DAOMAPTITKTDP1KDM4E | |
| SCHEMBL30409174 | 0.83 | CYP19A1 (0.54) | MAPTHPNHSP90AA1HSP90AB1TDP1 | |
| SCHEMBL30410032 | 0.83 | HPN (0.46) | MAPTHPNHSP90AA1TDP1KDM4E | |
| SCHEMBL8964895 | 0.73 | KDM4E (0.60) | DAOMAPTFLT3ITKTDP1 | |
| SCHEMBL10831846 | 0.72 | CYP1A1 (0.61) | MAPTFLT3ITKCYP1A1TDP1 | |
| SCHEMBL4887738 | 0.71 | KDM4E (0.64) | MAPTFLT3ITKCYP1A1TDP1 | |
| SCHEMBL5367030 | 0.69 | HSD17B1 (0.44) | DAOMAPTHSP90AA1HSP90AB1CYP2C19 | |
| Methane SCHEMBL28844909 | 0.69 | KDM4E (0.62) | MAPTFLT3ITKCYP1A1TDP1 | |
| SCHEMBL29362162 | 0.69 | PTPN22 (0.65) | MAPTTDP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102562-B | Naphtho [2,1-b ] indolo [2,3-d ] cyclooctalactone derivative and preparation method thereof | 江苏师范大学 | 2024-11-26 | — | — | CN | claimed |
| CN-116102562-A | Naphtho [2,1-b ] indolo [2,3-d ] cyclooctalactone derivative and preparation method thereof | 江苏师范大学 | 2023-05-12 | — | — | CN | claimed |
| CN-116102562-B | Naphtho [2,1-b ] indolo [2,3-d ] cyclooctalactone derivative and preparation method thereof | 江苏师范大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-116102562-A | Naphtho [2,1-b ] indolo [2,3-d ] cyclooctalactone derivative and preparation method thereof | 江苏师范大学 | 2023-05-12 | — | — | CN | disclosed |