Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 11/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 11/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149430 | 1.00 | PDK1 (0.36) | PDK1PDK2HSD11B1 | |
| SCHEMBL30412631 | 0.92 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30412602 | 0.92 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30414160 | 0.91 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30412376 | 0.91 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30413661 | 0.90 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30413215 | 0.90 | PDK2 (0.37) | PDK1PDK2 | |
| SCHEMBL30413560 | 0.84 | PDK2 (0.39) | PDK1PDK2 | |
| SCHEMBL30412647 | 0.84 | PDK2 (0.39) | PDK1PDK2 | |
| SCHEMBL30413227 | 0.83 | PDK2 (0.40) | PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240417406-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2024-12-19 | — | — | US | disclosed |
| EP-4438040-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023032940-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | 日本たばこ産業株式会社 | 2023-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240417406-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | PC, PCK2, AGK | PDK1 23/4885PDK2 5/4885HSD11B1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.