Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704430 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL2682785 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL9635522 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL2572678 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL116396 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL2202494 | 1.00 | POLB (0.50) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL7807921 | 0.89 | POLB (0.47) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL19262949 | 0.89 | CYP3A4 (0.46) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL7811172 | 0.89 | CYP1A2 (0.40) | POLBCYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL117368 | 0.89 | CYP1A2 (0.40) | POLBCYP1A2CYP3A4CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183616-A1 | NOVEL IONIZABLE LIPIDS AND LIPID NANOPARTICLES AND METHODS OF USING THE SAME | SENDA BIOSCIENCES, INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| EP-2993167-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | Ajinomoto Co., Inc. (JP) | 2016-03-09 | — | — | EP | disclosed |
| US-20160046592-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | AJINOMOTO CO., INC. (JP) | 2016-02-18 | — | — | US | disclosed |
| US-7651997-B2 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-01-26 | — | — | US | disclosed |
| US-20070129289-A1 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them | THE TRUSEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-06-07 | — | — | US | disclosed |
| EP-1276491-B9 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | UNIV PENNSYLVANIA (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1276491-B1 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | UNIV PENNSYLVANIA (US) | 2006-09-20 | — | — | EP | disclosed |
| US-7064105-B2 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-06-20 | — | — | US | disclosed |
| EP-1276491-A4 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | UNIV PENNSYLVANIA (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1276491-A1 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2001076616-A1 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129289-A1 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them | PRAP1, PTMA, DHPS | POLB 2323/4885CYP1A2 4305/4885CYP3A4 4131/4885 |
| US-20160046592-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | PPARG, GPR119, PPARA | POLB 2155/4885CYP1A2 638/4885CYP3A4 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.