Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ATF4 | P18848 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253512 | 1.00 | MMP2 (0.33) | MMP2ADAMTS5CYP11B2RAD51PDE4B | |
| SCHEMBL30494687 | 0.86 | GAA (0.31) | MMP2ADAMTS5CYP11B2 | |
| SCHEMBL24253616 | 0.86 | GAA (0.31) | MMP2ADAMTS5CYP11B2 | |
| SCHEMBL30494573 | 0.79 | GPR119 (0.42) | — | |
| SCHEMBL24253503 | 0.78 | RAD51 (0.34) | MMP2ADAMTS5CYP11B2RAD51 | |
| SCHEMBL30494655 | 0.78 | RAD51 (0.34) | MMP2ADAMTS5CYP11B2RAD51 | |
| SCHEMBL30424028 | 0.78 | DGAT1 (0.39) | — | |
| SCHEMBL24253513 | 0.78 | SLC6A3 (0.36) | MMP2ADAMTS5CYP11B2RAD51MMP13 | |
| SCHEMBL30423624 | 0.78 | SLC6A3 (0.36) | MMP2ADAMTS5CYP11B2RAD51MMP13 | |
| SCHEMBL24253629 | 0.75 | RAD51 (0.33) | MMP2ADAMTS5CYP11B2RAD51MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |