Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12442814 | 0.81 | KDM4E (0.62) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3963080 | 0.80 | GRM5 (0.58) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL23414745 | 0.79 | METTL3 (0.46) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2823070 | 0.77 | KDM4E (0.64) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10440196 | 0.77 | GRM5 (0.77) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8108255 | 0.76 | KDM4E (0.65) | KDM4EMAPTKMT2ASMN1; SMN2ADORA2A | |
| SCHEMBL7920089 | 0.76 | HSP90AA1 (0.49) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL32688229 | 0.75 | ALDH1A1 (0.50) | KDM4EHPGDMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL3958034 | 0.75 | KDM4E (0.55) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL823315 | 0.75 | ALDH1A1 (0.56) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | HAVCR2, HMBS, VHL | KDM4E 224/4885HPGD 1172/4885MAPT 4086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.