Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | OAT | P04181 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL1787821 | 0.98 | ALDH1A1 (0.36) | MMP8MMP1ALDH1A1CHRM2CHRM1 | |
| Cycloheptanamine SCHEMBL27746259 | 0.98 | ALDH1A1 (0.36) | MMP8MMP1ALDH1A1CHRM2CHRM1 | |
| Trifluoroacetic Acid SCHEMBL3708706 | 0.92 | OAT (0.34) | OATCHRM2CHRM1CHRM3F2 | |
| Trifluoroacetic Acid SCHEMBL3025153 | 0.92 | OAT (0.36) | OATALDH1A1DPP4DPP8DPP7 | |
| Trifluoroacetic Acid SCHEMBL3154232 | 0.90 | OAT (0.35) | OATALDH1A1F2PRSS1DPP4 | |
| Trifluoroacetic Acid SCHEMBL28133460 | 0.90 | OAT (0.35) | OATALDH1A1F2PRSS1DPP4 | |
| Trifluoroacetic Acid SCHEMBL7212392 | 0.86 | CHRM3 (0.36) | OATCHRM3SLC1A2 | |
| Trifluoroacetic Acid SCHEMBL31447631 | 0.86 | CHRM3 (0.36) | OATCHRM3SLC1A2 | |
| Trifluoroacetic Acid SCHEMBL7211625 | 0.86 | CHRM3 (0.36) | OATCHRM3SLC1A2 | |
| Trifluoroacetic Acid SCHEMBL8716042 | 0.86 | CHRM3 (0.36) | OATCHRM3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040932-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2013-02-14 | — | — | US | disclosed |
| US-8304434-B2 | Substituted aryl sulfone derivatives as calcium channel blockers | MERCK SHARP & DOHME CORP. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100210620-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | SCHERING CORPORATION | 2010-08-19 | — | — | US | disclosed |
| CN-101087757-A | Novel dipeptidyl peptidase iv inhibitors, process for their preparation and compositions containing them | GLENMARK PHARMACEUTICALS SA (CH) | 2007-12-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210620-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | TRPV1, TRPA1, CACNA1D | MMP8 941/4885MMP1 1623/4885OAT 4013/4885 |
| US-20130040932-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, TRPA1, CACNA1D | MMP8 941/4885MMP1 1623/4885OAT 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.