⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351216 | 0.62 | TRPA1 (0.38) | — | |
| SCHEMBL22474210 | 0.62 | HRH4 (0.33) | — | |
| SCHEMBL3892735 | 0.60 | AHR (0.40) | — | |
| SCHEMBL7834812 | 0.59 | MAOA (0.37) | — | |
| SCHEMBL169551 | 0.59 | MAOA (0.41) | — | |
| SCHEMBL24062 | 0.58 | MEN1 (0.37) | — | |
| SCHEMBL2514534 | 0.58 | LMNA (0.31) | — | |
| SCHEMBL2583571 | 0.57 | CYP2A6 (0.43) | — | |
| SCHEMBL8607730 | 0.56 | — | — | |
| SCHEMBL4680287 | 0.56 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099689-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2016-12-07 | — | — | EP | claimed |
| WO-2015114647-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-08-06 | — | — | WO | claimed |
| EP-1900726-A1 | Heterocyclic thioesters | MGI GP, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| EP-1626043-B1 | Heterocyclic thioesters | MGI GP INC (US) | 2007-12-12 | — | — | EP | claimed |
| EP-1083873-B1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | MGI GP INC (US) | 2006-08-09 | — | — | EP | claimed |
| EP-1626043-A1 | Heterocyclic thioesters | MGI GP, Inc. (US) | 2006-02-15 | — | — | EP | claimed |
| EP-0934263-B8 | NON-IMMUNOSUPPRESSANT FKBP ROTAMASE INHIBITORS | MGI GP INC (US) | 2006-01-18 | — | — | EP | claimed |
| EP-0934263-B1 | NON-IMMUNOSUPPRESSANT FKBP ROTAMASE INHIBITORS | GUILFORD PHARM INC (US) | 2005-11-23 | — | — | EP | claimed |
| US-20050059693-A1 | Heterocyclic thioester and ketone hair growth compositions and uses | GPI NIL HOLDINGS, INC. | 2005-03-17 | — | — | US | claimed |
| JP-2004538235-A | — | — | 2004-12-24 | — | — | JP | claimed |
| JP-2001506231-A | — | — | 2001-05-15 | — | — | JP | claimed |
| EP-1083873-A1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL Holdings, Inc. (US) | 2001-03-21 | — | — | EP | claimed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | claimed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | claimed |
| WO-2000009479-A2 | HETEROCYCLIC THIOESTERS OR KETONES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| WO-1999062488-A1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL HOLDINGS, INC. (US) | 1999-12-09 | — | — | WO | claimed |
| US-5990131-A | OF GIVEN FORMULA WHICH HAVE A HIGH AFFINITY FOR FKBPS (FK506 BINDING PROTEINS, A CLASS OF IMMUNOPHILINS) ARE POTENT ROTAMASE INHIBITORS AND EXHIBIT EXCELLENT NEUROTROPHIC EFFECTS; NO IMMUNOSUPPRESSIVE ACTIVITY | GPI NIL HOLDINGS INC. (US) | 1999-11-23 | — | — | US | claimed |
| EP-0934263-A1 | HETEROCYCLIC THIOESTERS AND KETONES | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | claimed |
| WO-1998013343-A1 | HETEROCYCLIC THIOESTERS AND KETONES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |