Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30440629 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL22326382 | 0.79 | ALDH1A1 (0.50) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL23944994 | 0.78 | MBOAT4 (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL23944461 | 0.77 | ALDH1A1 (0.55) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL25901621 | 0.76 | ALDH1A1 (0.53) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL11568741 | 0.76 | ALDH1A1 (0.47) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1285759 | 0.75 | ALDH1A1 (0.51) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8276259 | 0.74 | ABCB1 (0.56) | ALDH1A1ABCB1MAPTHPGDCTSL | |
| SCHEMBL11568854 | 0.74 | CTSS (0.45) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL22780788 | 0.74 | ALDH1A1 (0.50) | ALDH1A1ABCB1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473295-B2 | Substituted straight chain spiro derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2025-11-18 | — | — | US | disclosed |
| US-20230142285-A1 | SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473295-B2 | Substituted straight chain spiro derivatives | MLLT1, MEN1, MLLT3 | ALDH1A1 2388/4885ABCB1 3281/4885MAPT 3402/4885 |
| US-20230142285-A1 | SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES | MLLT1, MEN1, MLLT3 | ALDH1A1 2388/4885ABCB1 3281/4885MAPT 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.