Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 14/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736191 | 1.00 | L3MBTL1 (0.57) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL11964359 | 0.82 | NPC1 (0.43) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL25600283 | 0.81 | JAK2 (0.52) | PIK3C3JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL2642300 | 0.81 | L3MBTL1 (0.57) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL13165570 | 0.81 | TYK2 (0.66) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL91475 | 0.81 | ALDH1A1 (0.60) | L3MBTL1PIK3C3ALDH1A1CYP1A2 | |
| SCHEMBL19728666 | 0.80 | TYK2 (0.53) | TYK2ALDH1A1ACVRL1 | |
| SCHEMBL18785787 | 0.80 | LMNA (0.53) | L3MBTL1CYP1A2 | |
| SCHEMBL16311114 | 0.80 | JAK2 (0.53) | L3MBTL1JAK2JAK1TYK2ALDH1A1 | |
| SCHEMBL12975420 | 0.79 | L3MBTL1 (0.55) | L3MBTL1PIK3C3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430042-A1 | 6-HE TERO ARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2024-09-18 | — | — | EP | disclosed |
| CN-118201928-A | 6-Heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors | 艾捷斯治疗公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023086319-A1 | 6-HE TERO ARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |